The central character is Dr. Danielle “Danny” Simms, a third-year resident who experiences complex emotional and professional challenges. A key conflict involves Danny reporting Dr. Xander Phillips, a rich kid and fellow doctor, for sexual harassment. This accusation and its investigation create tension, especially as Xander is suspended but then brought back to help during a storm, while Danny is appointed interim chief resident. The relationship between Danny and Xander is complicated and portrayed with flashbacks that leave viewers uncertain about the truth. Additionally, Danny and her friend Dr. Sam Elijah both aspire to become chief resident, adding professional rivalry to the mix.

Danny's harassment claim against Xander creates a ripple effect throughout the hospital. Xander is initially suspended pending an investigation, but he is later brought back to help during a critical situation. Meanwhile, Danny is appointed as the interim chief resident, which leads to confusion and tension among the staff. The situation complicates the professional and personal relationships between the characters, especially between Danny and Xander.

Dr. Natalie Cruz is the founder of the unit at Maguire Hospital and plays a significant role in the story. She appoints Danny as the interim chief resident after Xander's suspension, which marks a pivotal moment in the series. Her leadership and decisions influence the dynamics and power struggles within the hospital.

The five most popular questions about the story content of Pulse (2025) that exclude the overall plot and ending are:

1. Who is the protagonist and what are her main challenges? (The protagonist is Danielle 'Danny' Simms, a 3rd-year resident doctor balancing personal and professional struggles at Maguire Hospital.)

2. What is the significance of the bus accident involving the high school soccer team? (It is the inciting incident that brings many characters together and sets the hospital drama in motion.)

3. How do the relationships and rivalries among the medical staff develop? (Notably, Danny has a professional rivalry with Sam Elijah, and Tom Cole is dismissive and rude to some colleagues.)

4. What role does Harper, Danny's younger sister, play in the story? (Harper is a wheelchair-bound junior resident at the hospital, adding a personal dimension to Danny's life.)

5. How does the hospital handle crises such as the hurricane and influx of patients? (The series depicts the hospital's response to emergencies, including a sexual harassment complaint and natural disasters.)

These questions reflect key story elements and character dynamics central to the series' content.