Fred and Rose West committed their crimes primarily in their home at 25 Cromwell Street, Gloucester, which became known as the 'House of Horrors.' They buried dismembered remains of victims in the backyard and cellar of the house. The series reveals that they kidnapped and killed women in broad daylight, with multiple human remains discovered on the property during investigations in 1994.

The series includes audio recordings of Fred West's interrogations, revealing him as a cold-blooded psychopath who speaks about his horrific acts with eerie matter-of-factness. His demeanor during these recordings shows a chilling lack of remorse and a disturbing eagerness in recounting his crimes.

The documentary features relatives of the victims, such as Belinda Mott and Dezra Chambers, who express ongoing pain and survivor's guilt. Belinda visits her sister's tombstone and emphasizes the importance of expressing love to family, while Dezra describes the process of talking about her sister Alison as cathartic and a step toward closure, highlighting the lasting emotional trauma caused by the Wests' crimes.

The series underlines that red flags about the Wests' actions were ignored by the police multiple times before their eventual arrest. It reveals gaps and negligence in the investigation, as the couple operated undetected for many years despite kidnapping and killing women in broad daylight. However, the show does not explicitly raise questions about this police negligence but highlights the survivor's guilt of the sole woman who escaped.

The series shows that Fred West died by suicide in his prison cell on January 1, 1995, before his trial concluded. Rose West was convicted and sentenced to life in prison; she has ceased appealing her sentence but continues to protest her innocence. The documentary also notes the fractured relationships among the Wests' surviving children and the ongoing public and familial pain caused by the case.