The series interweaves childhood footage showing Alex Cooper growing up in Newtown, Pennsylvania, as the youngest of three siblings, with a father in sports TV and a mother who was a psychologist. It highlights her time as a soccer standout at The Pennington School, revealing how these early experiences shaped her personality and voice as a podcaster.

The show traces Alex's evolution from a self-conscious college student to launching 'Call Her Daddy' after moving to New York City. It portrays the podcast's beginnings as a sex and dating show that eventually became the foundation of her media empire.

Call Her Alex includes intimate and emotional transparency about traumatic episodes in Alex Cooper's life, though the exact details are not specified in the available summaries. These moments are shown as pivotal in shaping her resilience and ambition.

The documentary follows Alex as she prepares for her first live tour, offering behind-the-scenes insights into the challenges and growth she experiences. This preparation is a key narrative thread demonstrating her rise from podcaster to media mogul.

The series highlights Alex's family background, including her father's career in sports TV and her mother's work as a psychologist, as influential factors. It also shows her as the youngest sibling, providing context for her personal development and the support system behind her success.