"Die Eifelpraxis" begins with Dr. Martin Winter, a dedicated and compassionate doctor, who has recently moved to the picturesque Eifel region of Germany. He is eager to establish his practice in the small town of Bad Münstereifel, where he hopes to make a difference in the lives of the local residents. The series opens with Martin arriving in the town, greeted by the charming yet quirky townsfolk, who are both welcoming and curious about the new doctor.

As Martin settles into his new life, he faces the challenges of adapting to a rural practice. He quickly realizes that the community has its own unique dynamics and that he must earn the trust of the locals. One of his first patients is a young girl with a mysterious illness, which sets the stage for Martin's determination to uncover the truth behind her condition. This case introduces him to the complexities of rural medicine, where resources are limited, and he must rely on his instincts and knowledge.

In the following episodes, Martin develops a close relationship with his nurse, Dr. Julia Schmitt, who is both supportive and skeptical of his methods. Their professional dynamic is tested as they navigate various medical cases together, including a farmer with a severe injury and an elderly woman suffering from chronic pain. Martin's empathetic approach often clashes with Julia's more pragmatic view, leading to tension but also growth in their partnership.

As the series progresses, Martin becomes increasingly involved in the community, attending local events and forming friendships with residents. He learns about the town's history and the personal struggles of its inhabitants, which deepens his commitment to his practice. One significant plot point occurs when Martin discovers a pattern of health issues linked to a local factory, prompting him to investigate further. This revelation puts him at odds with some townspeople who are reluctant to confront the factory's impact on their lives.

A turning point in the series comes when Martin faces a personal crisis. He receives news that his estranged father is gravely ill, forcing him to confront unresolved feelings about their relationship. This subplot adds emotional depth to Martin's character, as he grapples with his past while trying to maintain his responsibilities in the present. His internal struggle is mirrored in his interactions with patients, as he becomes more attuned to their emotional needs.

In a dramatic episode, a severe storm hits the Eifel region, causing widespread damage and isolating the town. Martin and Julia must work together to provide medical care to those affected, showcasing their teamwork and resilience. During this crisis, they encounter a life-threatening situation when a patient requires immediate surgery, and they must improvise with limited resources. This high-stakes moment solidifies their bond and highlights Martin's dedication to his patients.

As the season progresses, Martin's investigation into the factory's health risks leads to a confrontation with the factory owner, who threatens to undermine his practice and reputation. This conflict escalates, forcing Martin to make a difficult decision about whether to prioritize his career or stand up for the community's health. His choice to advocate for the townspeople ultimately strengthens his position in the community, but it also alienates some residents who fear the repercussions.

The series culminates in a heartfelt finale where Martin reflects on his journey and the relationships he has built. He reconciles with his father, finding closure and understanding. The town comes together to support Martin in his fight against the factory, demonstrating the strength of community bonds. The final scenes depict Martin fully integrated into the town, having earned the trust and respect of the residents, setting the stage for future challenges and triumphs in his practice.

Dr. Döring encounters various challenges in his medical practice, including dealing with the unique health issues of the rural population, navigating the complexities of local relationships, and managing the expectations of his patients while trying to maintain a work-life balance.

The relationship between Dr. Döring and his assistant, who initially has a professional demeanor, gradually deepens as they face personal and medical challenges together, leading to moments of vulnerability and mutual support that strengthen their bond.

The local community is central to the storylines, as Dr. Döring often finds himself entangled in the lives of his patients, which leads to both comedic and dramatic situations that highlight the interconnectedness of the villagers and their reliance on each other.

Dr. Döring's past, including his previous experiences in a larger city hospital, influences his approach to medicine and patient care, often causing him to reflect on his choices and the reasons he chose to practice in the Eifel region, which adds depth to his character.

The series features various medical cases, such as a patient with a rare illness or a community health crisis, which not only challenge Dr. Döring's medical skills but also reveal the emotional struggles of the patients and their families, ultimately impacting the relationships and dynamics within the community.