In Predator: Killer of Killers, the three main characters are given weapons from their own times: Ursa wields an axe, Kenji uses a sword, and Torres is armed with a flintlock pistol during their fight against the Warlord Predator and other threats.

Ursa sacrifices herself to allow Torres and Kenji to escape by staying behind to break a harpoon anchoring their ship, after which she is captured and put into stasis alongside other humans who have killed Predators, including Naru from Prey.

Kenji and Kiyoshi are brothers and sons of a samurai warlord; Kenji refuses to duel Kiyoshi to determine their father's successor, leading to Kiyoshi defeating him and Kenji fleeing. Years later, Kenji returns, defeats Kiyoshi in a sword fight, and together they fight a Predator, ultimately killing it, though Kiyoshi dies from his injuries.

The collars worn by Ursa, Kenji, and Torres can be activated by the Warlord Predator to kill them instantly if they refuse to fight. However, the collars deactivate and fall off after Torres escapes from a giant beast and frees the others, allowing them to continue their battle and attempt escape.

The Warlord Predator is the main antagonist who forces Ursa, Kenji, and Torres to fight by threatening them with explosive collars. It unleashes a gigantic beast against them, fires a harpoon to anchor their ship, and ultimately leads a squadron of ships to hunt the survivors after Ursa's sacrifice.