The main conflicts arise when one couple, Nick and Anne, announce their separation, and Nick introduces his much younger girlfriend, Ginny, into the group. This disrupts the group's dynamic and forces the friends to confront issues of aging, fidelity, and evolving relationships. Additionally, tensions surface around open marriages, jealousy, and personal struggles such as Danny feeling smothered by Claude and Nick's discomfort with Ginny's past relationships.

The characters cope by attempting to maintain their tradition of quarterly vacations despite the upheavals. They engage in moments of reconciliation, such as Jack and Kate making up after conflicts, and Ginny and Nick officially becoming a couple. They also face personal challenges, like Anne confronting her feelings about Nick and Ginny, and Danny dealing with his relationship with Claude. The group supports each other through crises, including evacuations due to a hurricane and personal health issues.

Open marriages are a significant theme explored through the characters Claude and Danny, who mention their open marriage, and Ginny, who reveals her last relationship was also open. This theme contributes to the tension and discomfort among the group, particularly affecting Nick, who is uneasy with Ginny's past relationships. It highlights the complexities and evolving nature of modern relationships within the group.

Nick's death in a tragic car accident on New Year's Eve profoundly affects the group. His ex-wife Anne extends an olive branch to his pregnant girlfriend Ginny, inviting her into their found family. This event brings both tragedy and uplift, as the characters navigate grief, acceptance, and the challenge of moving forward without Nick. The storyline deviates from the original film by focusing on this new family dynamic and the impending arrival of Nick's child.

Key moments include Anne deciding not to confront the group and instead finding catharsis in smashing souvenirs, Danny feeling smothered by Claude and struggling with drug use, and Nick injuring his foot while trying to impress Ginny. The group also experiences bonding moments, such as a drunken night of dancing led by Ginny and collective efforts to support each other during a hurricane evacuation. These scenes reveal their vulnerabilities, personal struggles, and efforts toward growth and understanding within their friendships.

In the TV show The Four Seasons produced in 2025, a major character does die: Nick, played by Steve Carell. His death occurs in a car accident during the penultimate episode of Season 1. The circumstances are as follows:

• Nick spends New Year's holidays apart from his friends, with his girlfriend Ginny and her friends. After a fight during a ski trip, Ginny goes hiking with her friends, while Nick goes alone to make a grocery run.
• On his way back from the store, Nick is involved in a fatal car accident and dies.
• The last episode focuses on his funeral and how his close friends and ex-wife Anne cope with the loss and the complex emotional dynamic with Ginny, who feels excluded from the funeral arrangements.
• The series concludes with the group mourning together, reconciling with Ginny, and planning their next trip in Nick's honor. It is also revealed that Ginny is pregnant with Nick's child.

Steve Carell himself was reportedly disappointed by his character's death, as it prevented him from returning for Season 2. This death is a significant departure from the original The Four Seasons movie, where Nick's character does not die.