During their journey, Ewan McGregor and Charley Boorman immerse themselves in various unique cultural experiences such as sampling Scandinavian seaweed cuisine, meeting traveling musicians busking around Europe, visiting the world's largest nonprofit NGO warehouse in Copenhagen (a UNICEF facility), and engaging with local groups like German shooting club members. They also interact with locals like Hugo, a Swedish teenager with a low-speed learner's car, and experience diverse activities including day drinking and swimming in the Baltic Sea.

Ewan McGregor and Charley Boorman ride refurbished vintage motorcycles throughout their journey. These bikes are notable for being vintage models that have been restored for the trip, emphasizing a connection to classic motorcycling culture rather than modern machines.

The support vehicles used in Long Way Home are Rivian electric trucks, which have been a part of their previous 'Long Way' series as well. Although these vehicles are barely mentioned in the series, they provide logistical support for the motorcycle journey, highlighting a blend of vintage motorcycling with modern electric vehicle technology.

Throughout the journey, Ewan and Charley encounter mechanical issues such as bent frame parts on their motorcycles, which lead them to seek help from local biker clubs like Malmo's 'Odd Luck Garage.' They also face varied weather conditions and navigate hairpin-turn roads, which test their riding skills and endurance.

The journey covers more than fifteen countries, starting from Ewan McGregor's home in Scotland, crossing the North Sea to Scandinavia, traveling up to the Arctic Circle, then down through the Baltics and continental Europe, before finally crossing back over the English Channel to Charley Boorman's home in England. The route is deliberately circuitous, taking them through spectacular scenery and some of the world's greatest driving roads.