Episode 2 "Rose" explores Rose West's tragic upbringing, providing insight into her early life and how it may have influenced her later actions alongside Fred West. The episode delves into her background more deeply than the first episode, highlighting factors that shaped her character and role in the crimes.

As the investigation unfolds in episode 2, the police learn more about the dark and twisted relationship between Fred and Rose West. They deduce that Fred could not have acted alone, indicating Rose's active involvement in the crimes. This episode focuses on uncovering the couple's joint participation and the extent of their collaboration in the murders.

Episode 2 features relatives of the Wests' victims, such as Belinda Mott, whose sister Juanita Mott's remains were found in the Wests' cellar. The episode shows Belinda visiting her sister's tombstone and expressing the lasting pain caused by the crimes. It also includes Dezra Chambers, who talks about her sister Alison and the catharsis of discussing the crime, highlighting the victims' families' perspectives.

While episode 2 focuses on the investigation and the couple's relationship, it hints at the possibility of more victims beyond those confirmed. The police deduce Fred could not have acted alone, implying Rose's involvement in multiple murders. However, the documentary does not fully explore the possibility of other victims or new discoveries in detail.

Episode 2 touches on Rose West's psychological background and motivations, including her tragic upbringing and how Fred West, a pedophile, may have influenced her. The episode attempts to provide some understanding of her mindset and role in the crimes, though critics note the documentary does not deeply analyze the psychological dynamics between the two.