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Season 20 only saw one departure this time, comedian Michelle Collins, however it did see the addition of three new co-hosts: journalist Sara Haines, lawyer Sunny Hostin, and author Jedediah Bila.
- Episode 1: Tracy Morgan
- Episode 2: Episode 2
- Episode 3: Gov. Gary Johnson
- Episode 4: Mary J. Blige & Maxwell/Gigi Hadid & Tommy Hilfiger/Chelsea Clinton
- Episode 5: Dr. Phil McGraw/Harry Connick Jr.
- Episode 6: Episode 6
- Episode 7: Joseph Gordon-Levitt
- Episode 8: The Beach Boys
- Episode 9: Keke Palmer
- Episode 10: Valerie Jarrett/Laith De La Cruz & Dominique Jackson
- Episode 11: Jamie Lee Curtis/Cookie Johnson/Kellyanne Conway
- Episode 12: Anthony Anderson/Dancing with the Stars Couple
- Episode 13: Lisa Ling/Kellyanne Conway/Surprise Music Performer
- Episode 14: Geena Davis
- Episode 15: Episode #20.15
- Episode 16: Robby Mook/Common
- Episode 17: Kiefer Sutherland
- Episode 18: Kellyanne Conway/Lupita Nyong'o & David Oyelowo
- Episode 19: Hayley Atwell/Colin Jost & Michael Che
- Episode 20: Sheryl Cross/Mindy Kaling/Gretta Monahan
- Episode 21: Issa Rae
- Episode 22: Kelly Clarkson
- Episode 23: Sela Ward
- Episode 24: Elizabeth Vargas
- Episode 25: Hot Topics/View Your Deal
- Episode 26: Meredith Vieira
- Episode 27: Nancy Grace
- Episode 28: Sen. Tim Kaine & Anne Holton/Neil DeGrasse Tyson
- Episode 29: Wendy Williams
- Episode 30: Clay Aiken/View Your Deal
- Episode 31: Episode 31
- Episode 32: Martha Raddatz
- Episode 33: Tyler Perry
- Episode 34: Sen. Al Franken/Daphne Oz
- Episode 35: Episode #20.35
- Episode 36: Dana Perino/Will Forte
- Episode 37: Phil Collins
- Episode 38: Nathan Lane, John Goodman & John Slattery
- Episode 39: Ewan McGregor & Dakota Fanning
- Episode 40: Halloween 2016
- Episode 41: Hot Topics/Tom Bergeron
- Episode 42: Kellyanne Conway/Hot Topics
- Episode 43: Robby Mook/Hot Topics
- Episode 44: Chris Wallace/Hot Topics
- Episode 45: Hot Topics/Hot Affordable Items
- Episode 46: Ana Navarro
- Episode 47: Episode 47
- Episode 48: Tom Selleck/Timothy Birckhead
- Episode 49: Guest Co-Hosts Meredith Vieira, Star Jones & Debbie Matenopoulos/Priyanka Chopra
- Episode 50: Whoopi's Birthday/Sen. Bernie Sanders
- Episode 51: Rascal Flatts/Adam Glassman
- Episode 52: Lin-Manuel Miranda
- Episode 53: Megyn Kelly/Simone Biles
- Episode 54: Cast of "Fantastic Beasts and Where to Find Them"
- Episode 55: Garth Brooks/Hot Affordable Items
- Episode 56: Kathy Griffin
- Episode 57: Martha Stewart/Jean Bell/"Dancing with the Stars" Winners and Runners-Up
- Episode 58: Billy Bob Thornton
- Episode 59: Sarah Jessica Parker
- Episode 60: Neil Patrick Harris/Tim Tebow
- Episode 61: Jill Stein/Tom Ford
- Episode 62: Van Jones/Hot Topics
- Episode 63: Holland Taylor
- Episode 64: Steve Harvey/Helen Mirren
- Episode 65: Queen Latifah/Andy Cohen
- Episode 66: DJ Khaled
- Episode 67: Jodie Sweetin & Andrea Barber
- Episode 68: Episode 68
- Episode 69: Episode 69
- Episode 70: Kellyanne Conway/Ali Wentworth
- Episode 71: Taraji P. Henson/Whoopi's Favorite Holiday Things
- Episode 72: Episode 72
- Episode 73: Patti LaBelle/Darlene Love
- Episode 74: Episode 74
- Episode 75: Naomi Campbell/Hot Topics
- Episode 76: Episode 76
- Episode 77: Episode 77
- Episode 78: Episode 78
- Episode 79: Gabrielle Union
- Episode 80: Episode 80
- Episode 81: Charlie Sheen/Clay Aiken
- Episode 82: Vice President Joe Biden & Dr. Jill Biden/Diane Sawyer
- Episode 83: Van Jones/Arno Michaelis/Pardeep Singh Kaleka/Clay Aiken/Sunny Hostin
- Episode 84: Episode #20.84
- Episode 85: Bryce Dallas Howard/Jerry O'Connell & Rebecca Romjin
- Episode 86: Cokie Roberts/Jim Gaffigan
- Episode 87: Crisela Alonzo
- Episode 88: Samantha Power
- Episode 89: Episode #20.89
- Episode 90: James Monroe Iglehart/Broadway's "Aladdin"
- Episode 91: Guest Co-Hostess Gretchen Carlson/Omarosa Manigault
- Episode 92: Sybrina & Tracy Martin/View Your Deal
- Episode 93: Keke Palmer/Hot Topics
- Episode 94: Michael Eric Dyson/Johnny Galecki
- Episode 95: Dr. Phil McGraw
- Episode 96: Guest Co-Host Jason Biggs/Robert DeNiro
- Episode 97: Sarah Michelle Gellar
- Episode 98: "Day of Hot Topics"
- Episode 99: Tracee Ellis Ross; Elizabeth Warren
- Episode 100: Priyanka Chopra; Will Arnett
- Episode 101: Lena Dunham
- Episode 102: Day of Hot Topics; View Your Deal
- Episode 103: Holly Robinson Peete and Rodney Peete; Newlywed Game
- Episode 104: Bob Odenkirk
- Episode 105: Ice Cube
- Episode 106: Trevor Noah
- Episode 107: Lindsay Lohan; Darrell Hammond
- Episode 108: Charles Schumer
- Episode 109: Eva Longoria
- Episode 110: Henry Louis Gates Jr.
- Episode 111: Howie Mandel
- Episode 112: David Hyde Pierce
- Episode 113: Tara Setmayer
- Episode 114: Aubrey Plaza
- Episode 115: Patrick Stewart
- Episode 116: Jennifer Lopez; Jennifer Beals
- Episode 117: John Stamos; Andy Grammer
- Episode 118: Ariel Winter; Sherri Shepherd
- Episode 119: Eric Stonestreet; Audra McDonald
- Episode 120: Mandy Moore; James Cameron
- Episode 121: Tom Bergeron; Train; Masaharu Morimoto; Art Smith
- Episode 122: Gillian Anderson and Jennifer Nadel; Adam Glassman
- Episode 123: Trae Crowder, Corey Ryan Forrester and Drew Morgan
- Episode 124: Day of Hot Topics
- Episode 125: Regina King; Maksim Chmerkovskiy
- Episode 126: Tomi Lahren
- Episode 127: Sanaa Lathan and Mack Wilds
- Episode 128: Joe Manganiello
- Episode 129: Rachel Maddow; Bruce Feiler
- Episode 130: Kristen Bell and Dax Shepard
- Episode 131: Anthony Anderson
- Episode 132: Jane Fonda and Lily Tomlin
- Episode 133: Day of Hot Topics
- Episode 134: Katie Holmes
- Episode 135: Day of Hot Topics
- Episode 136: Alex Rodriguez; Katey Sagal
- Episode 137: Day of Hot Topics; View Your Deal
- Episode 138: Day of Hot Topics
- Episode 139: Helen Hunt
- Episode 140: Morgan Freeman, Michael Caine and Alan Arkin; T.I.
- Episode 141: Kurt Russell
- Episode 142: Marc Summers; Tyrese Gibson
- Episode 143: Kelly Rowland; Bill Nye; Dance Theatre of Harlem
- Episode 144: Sherrie Westin; Susan Sarandon; Jack Hanna
- Episode 145: Martha Stewart; Tyson Beckford
- Episode 146: Jackie Evancho and Juliet Evancho
- Episode 147: Lori Greiner
- Episode 148: Charlamagne Tha God
- Episode 149: Elizabeth Warren; Julian Lennon
- Episode 150: Anne Hathaway; Matthew Dowd
- Episode 151: Cynthia Nixon
- Episode 152: Allison Janney; Adam Glassman
- Episode 153: John Kasich; Kelly Osbourne
- Episode 154: Caitlyn Jenner
- Episode 155: Dr. Phil; Sheryl Sandberg and Adam Grant
- Episode 156: Salma Hayek and Eugenio Derbez; Ian Smith
- Episode 157: Ann Coulter
- Episode 158: LeAnn Rimes
- Episode 159: Drew Pinsky
- Episode 160: Day of Hot Topics
- Episode 161: Deion Sanders; Wanda Sykes
- Episode 162: Kirsten Gillibrand
- Episode 163: Condoleezza Rice; Ashley Graham
- Episode 164: Mayim Bialik
- Episode 165: Patti LaBelle; Drew Brees
- Episode 166: Day of Hot Topics
- Episode 300: Hari Kondabolu
