Ray and Manny are best friends who start the series by posing as DEA agents to rob low-level drug dealers and operations in Philadelphia. Their motivation is to escape a cycle of crime they never agreed to be part of, trying to make money within a moral gray area while avoiding more dangerous criminal factions.

The arrival of a third character, an unpredictable prison friend of Ray's, promises a lucrative payday outside the inner city but leads to a botched robbery involving multiple deaths and more drugs and money than anticipated. This event triggers the main conflict, with Ray and Manny trying to escape various factions including a biker gang, the cartel, and federal agents.

Ray and Manny face shootouts, ambushes set by biker gangs, threats from the cartel, and pressure from federal agents. They are outsmarted at times and must navigate a dangerous underworld while trying to protect their families and themselves.

Family relationships are significant in the narrative. Ray's mother Theresa returns home demanding the truth and is involved in efforts to protect family members. Ray's incarcerated father Bart is also part of the story, with his stabbing in prison affecting the plot. Manny seeks help reconciling with Sherry, who threatens to turn him in, showing the personal stakes involved.

Law enforcement, including the DEA and local police, are actively pursuing Ray and Manny after the botched robbery. The DEA recovers evidence linking to Ray, and local police conduct mass arrests to thwart biker gang ambushes. Meanwhile, criminal factions such as biker gangs and the cartel are also hunting them, creating a multi-front conflict.