The five most popular story-related questions about Devil May Cry Season 1 Episode 1 'Inferno' are:

1. What is the significance of the White Rabbit character introduced in this episode?
2. How does Dante's demon-hunting career and abilities develop or get portrayed in this first episode?
3. What role does Mary play in the story, and how is her character introduced or developed?
4. What are the key conflicts or antagonists introduced in 'Inferno'?
5. How does the episode set up the moral or thematic dilemmas regarding demons and humanity?

These questions focus on the episode's characters, conflicts, and thematic elements rather than the overall plot or ending.