In episode 5 'Descent', Dante undergoes a significant transformation revealing his partial demon nature, which activates special abilities linked to his father Sparta. This demonic transformation is crucial as it triggers something unique in his DNA, making his blood essential for the White Rabbit's plan. Dante's Devil Trigger form is visually striking but controversial among fans due to its CGI animation. This episode forces Dante to confront his demon side more directly than before.

The episode reveals that the demons are not mindless monsters but refugees from the demon realm Makai, manipulated and controlled by the White Rabbit. Mary discovers the White Rabbit's true goal is revenge against DARKCOM. Despite Mary's efforts to protect the demon refugees, Vice President Baines orders their extermination, escalating the conflict and leading to a deadly confrontation where many agents are killed in an explosion caused by Plasma, who then commits suicide.

The White Rabbit is a mysterious antagonist who manipulates demon refugees and seeks Dante's blood to fulfill a larger plan involving breaking down barriers between realms. His goal is revenge against DARKCOM, and he threatens to unleash his demon army if Dante does not surrender. The episode uncovers his experiments and his control over the demons, making him a central figure in the escalating conflict.

The episode opens with a dramatic free fall after the destruction of Air Force 2, involving Dante, Enzo, Vice President Baines, and others. This sequence is notable for its mix of humor and action, showcasing character dynamics, especially between Enzo and Baines. It also leads into Dante's epic transformation into his Devil Trigger form, marking a pivotal moment in the episode's narrative and visual presentation.

Mary faces grim discoveries that complicate her mission, including uncovering the true nature of the demons and the White Rabbit's manipulations. She reunites with the disguised Plasma, whom she recognizes when he refers to Hell by its demon name 'Makai'. Mary kills Echidna during an ambush and delivers a speech urging DARKCOM reinforcements to evacuate the demon refugees. Her leadership and resolve are tested as she navigates the escalating crisis and moral complexities of protecting demon refugees against DARKCOM's orders.