The five most popular story-related questions about Devil May Cry Season 1, Episode 8 'A River of Blood and Fire' are:

1. How does Dante's Devil Trigger transformation occur and what triggers it in this episode?
2. What role does Lady play in the events of this episode, especially regarding her relationship with Dante?
3. How is Vergil introduced or revealed in this episode, and what significance does his appearance have?
4. What is the outcome of the battle between Dante and the White Rabbit in this episode?
5. How does the episode set up future storylines, particularly concerning the fate of Dante and the demon world?

These questions focus on key plot developments such as Dante's transformation, Lady's betrayal, Vergil's reveal, the climax fight, and the setup for the next season, all central to the episode's narrative content.