A young film studies professor at Blackmore University, Laura Crane, answers what she believes is a message from a student and arranges to meet. A man named Jason Carvey, one of Laura's pupils, has been manipulating her online; when she arrives he dons a Ghostface disguise and murders her. In the aftermath, Jason confides in his roommate Greg Bruckner and together they sketch out a plan to finish the story that Richie Kirsch and Amber Freeman began in Woodsboro by targeting sisters Samantha "Sam" and Tara Carpenter. Before they can act, a phone interrupts Jason: the voice on the line belongs to another Ghostface. That intruder ambushes Greg, killing him, then turns on Jason and stabs him to death, leaving the staged killing of Laura exposed as a first step in a new, larger plot.

One year after the Woodsboro rampage, Sam and Tara have relocated to New York City. Tara enrolls at Blackmore University while Sam struggles with public vilification: online conspiracy theorists accuse her of being the architect of the previous killings, claiming she framed Richie and Amber. The Meeks-Martin twins, Mindy and Chad, move to New York with them; Mindy brings her girlfriend Anika Kayoko, and Chad shares an apartment with a college friend, Ethan Landry. Quinn Bailey, a fellow student and Tara's roommate, lives with them as well. Sam attends regular therapy sessions with Dr. Christopher Stone in an effort to manage the trauma and the media scrutiny, but authorities are still probing the case when Detective Wayne Bailey--Quinn's father--contacts Sam. Bailey summons her to the NYPD precinct after Sam's identification is found at the scene of Jason's murder and a Ghostface mask associated with the original Woodsboro killers is discovered near Laura's body.

While Bailey's officers transport Sam toward the station, Sam receives a phone call that appears to come from Richie Kirsch's number. The voice on the line taunts her, and during the chaos that follows Tara narrowly escapes an attack but the assailant does not stop there. A Ghostface appears inside a Manhattan bodega: he slaughters several unsuspecting customers in quick, brutal fashion and moves through the store with a knife, leaving behind a mask that matches the version worn during the 2011 Woodsboro murders. The massacre sends New York law enforcement into a full response and triggers FBI involvement. At the precinct Sam encounters a familiar face: Kirby Reed, a survivor of the 2011 killings who now works with the FBI on the case. Reporter Gale Weathers also arrives; she has written a new book about the Woodsboro events despite previously assuring Sam and Tara she would not exploit their trauma. Gale tells them that Sidney Prescott has gone into hiding to safeguard her family.

Ghostface escalates the campaign against Sam. Dr. Christopher Stone, Sam's therapist, is murdered in his office: the killer rips open his chest with a knife and takes Sam's confidential file before departing, leaving behind a Ghostface mask that matches the one worn in the Hollywood killings. At Sam and Tara's apartment Danny, Sam's boyfriend, looks out his window and witnesses a figure in the familiar Ghostface costume force entry into the building. He sees the assailant stab Quinn Bailey in the chest in the corridor before the killer bursts into the sisters' apartment and attacks their friends. Anika Kayoko is stabbed to death on the floor of the living room; the assailant moves with practiced cruelty and abandons yet another distinct Ghostface mask, this one used in the Windsor College murders. Danny calls from his window and alerts the group, but the killer slips away into the city before the police can contain him.

Gale, having discovered an abandoned movie theater on investigation, proposes using it as a trap. The derelict cinema has been transformed into a macabre shrine: shelves and displays hold evidence collected from the various Ghostface killings, props and photographs of past killers set up like a fan's memorabilia. Gale believes the killer will be drawn to the idolization of his predecessors and agrees to lure him there. As detection and paranoia grow, Mindy and Chad brainstorm: Mindy suggests the murderer is following the "rules" of horror franchises--anyone can die while the series continues--which prompts them to look for patterns in the masks and the evidence left at each scene.

While moving around the city the group splits up. Mindy catches a late-night subway and during the ride a Ghostface boards: he forces himself through the car and slashes Mindy in the abdomen with a knife. She collapses bloodily onto the floor; passengers shout and scatter, and the assailant disappears through the car doors. Mindy survives but is gravely injured and later transported to hospital. The remaining group members converge at the old theater, intending to bait the killer into an ambush.

Inside the theater, Sam begins to have disturbing visions of Billy Loomis, her biological father and one of the original Woodsboro murderers. Her hallucination manifests with uncanny clarity, and as she struggles with the image she reaches and takes hold of a familiar blade: Billy's original knife from the first murders is housed among the theater's exhibits, and Sam grips it, the metal cold in her hand. As the group moves through the lobby and projection rooms, the exits slam and lock behind them; someone has sealed the doors. Two Ghostface attackers emerge and assault Chad, stabbing him repeatedly as he tries to fend them off. Blood sprays across the theater carpets as Chad is wounded. The Carpenters and their remaining friends scramble; the theater falls into chaos.

Shots ring out from the street as Detective Wayne Bailey and Kirby arrive, guns drawn. Bailey barges into the venue, calls for the killers to stop, and then opens fire--but his shot goes astray and hits Kirby, wounding her. He immediately rips off the Ghostface hood he has been wearing, revealing that he is the third Ghostface inside the theater. Two accomplices materialize beside him: Ethan Landry and Quinn Bailey. Quinn, who Tara and the others believed dead from the earlier stabbing, removes her own mask, showing she faked her death to earn trust and get close to the sisters. Ethan, Chad's college roommate, grins and steps forward; he pulls off his mask as well. The three of them stand together and confess their plan.

They explain their motivation aloud: Richie Kirsch was Wayne Bailey's first-born son, the brother of Quinn and Ethan by blood; after Richie's death, the family fell apart and the Meeks-Martin twins bore public blame through accusations against Sam. The trio reveal they engineered the smear campaign that turned public sentiment against Sam and infiltrated her life in the city to exact revenge. Their intent is to finish the narrative Richie began, to punish Sam for what they insist she did. Quinn taunts Sam with stories about the way Richie's memory was twisted online. Ethan and Quinn wield knives; Wayne moves with quiet fury and a policeman's calm, indicating his experience with firearms and procedure.

A pitched fight ensues. Tara lunges at Quinn, striking and cutting, but Quinn fights back with practiced cruelty. Ethan, working as Bailey's other blade, slashes toward Tara and Mindy. Tara manages to land a savage blow: she plunges a knife deep into Ethan's mouth and throat, driving the blade in until he gurgles and falls back, hands clutching his face as blood pours from his mouth. Ethan's body convulses and he crashes against a projection screen. Sam confronts Quinn and the two clash; Quinn raises a weapon, but Sam draws a handgun and fires point-blank, shooting Quinn through the skull and killing her instantly. Quinn collapses, her life extinguished by the bullet that passes through her head.

Sam turns her attention to Wayne. He takes a step toward her with a gun, confident in his authority and his familial justification. Sam moves closer and, reciting nothing, attacks with the blade she took from her father's belongings. She stabs Wayne repeatedly in the chest and abdomen, an assault of brutal, relentless strikes. Blood sprays his shirt as he staggers backward. Finally, Sam drives a final, decisive blow: she plunges the knife into his eye, piercing bone and brain, and Wayne slumps to the ground. The theater echoes with the sounds of the wounded and the dying.

Ethan is not yet dead. He seizes the moment to lurch back to his feet and rush Sam with a wild, bloody fury. Kirby, despite having been shot earlier and bleeding, drags herself forward; she grabs an old CRT television from the theater's display--the same kind of set Sidney Prescott once used to kill Stu Macher--and lifts it above her head. With a last, violent effort she hurls the television down onto Ethan's skull. The heavy instrument smashes across his face; the impact cracks his skull open and his head crumples beneath the weight. Ethan ceases movement as blood and brains spread across the theater floor. Kirby collapses, exhausted and wounded, but she has ended the final immediate threat.

Outside, emergency crews flood the block. Police officers secure the theater and call for ambulances. The wounded are loaded into ambulances: Mindy is stretchered out and driven to the hospital, Chad is treated for multiple stab wounds and transported as well, and Kirby is taken for urgent medical care after her gunshot wound and her exertions. Gale is placed into an ambulance too; earlier, Ghostface attacked her in her apartment, killing her boyfriend during the assault and nearly strangling and stabbing Gale herself before the Carpenter sisters intervened. Gale survives but is shaken and injured.

In the aftermath at the theater, detectives and agents piece together the conspiracy: Wayne Bailey had hidden his ties to Richie and harbored a deep rage over the previous killings and the way his family had been splintered. He recruited his two children, Quinn and Ethan, grooming them into killers who could execute a plan that blurred the line between vengeance and fandom. The online campaigns and planted evidence had been their doing all along, intended to isolate Sam and push her into dangerous corners. The trio's staged deaths and false clues had been designed to keep them off the police radar until they chose to strike in person.

Sam faces the wreckage of what occurred. She removes the Ghostface costume she finds on Wayne's body--the one built from her father's mythos--and puts it on for a calculated moment, mimicking the voice on the phone that had tormented her for months. She uses a phone to call one of the officers watching the street, echoing the words she had heard during the attacks, and taunts Wayne even as he lies dying beneath her knife. When he finally bleeds out, she releases the costume and stands over the carnage, breathing hard. She chooses to discard the mask into a trash bin outside the theater, letting go of the tangible link to the legacy that has stalked her life.

At the hospital, medics wheel the survivors into emergency rooms. Chad and Mindy receive treatment for stab wounds; Mindy undergoes surgery for multiple lacerations and blood loss, and Chad is treated for deep puncture wounds but is stabilized. Kirby receives care for the gunshot wound and for concussion-like symptoms from the television strike. Gale remains under observation for the injuries inflicted during Ghostface's assault and for the shock of losing her partner. Sam and Tara each speak with officers and with FBI personnel; Tara agrees to begin regular therapy sessions to address the trauma she has endured, and Sam makes a conscious decision to allow Tara more independence, to stop micromanaging her sister's life.

Before she leaves the hospital, Sam retrieves Billy Loomis's knife from evidence placed in temporary custody at the precinct; she examines the handle and the old, nicked blade for a long moment. Rather than keep the weapon as a token of lineage, she tosses it into a dumpster behind the hospital and walks away. In a final scene on a city street, Sam joins Tara and Danny as they cross a busy Manhattan intersection. Officers and detectives move among the press and the gawkers; Kirby, Chad and Mindy are photographed being wheeled into ambulances and loaded into vans that will take them to be questioned and treated. Sam glances once at the discarded mask and knife behind her and then continues forward. She refuses to remain a puppet to the saga written by other people's violence. She follows Tara and Danny into the stream of commuters and disappears into the dense flow of New York City, leaving behind the ruins of the theater and the bodies that paid for a family's revenge.

In the ending of Scream VI, the surviving characters confront the Ghostface killer in a climactic showdown. Sam and Tara Carpenter, along with their friends, face off against the new Ghostface, who reveals their identity and motivations. The final confrontation leads to a tense battle, resulting in the defeat of the killer. The film concludes with a sense of closure for the characters, but leaves an open-ended question about the legacy of Ghostface.

As the film approaches its climax, the atmosphere is thick with tension. The scene opens in a dimly lit, abandoned theater, where Sam Carpenter, played by Melissa Barrera, and her sister Tara, portrayed by Jenna Ortega, gather with their friends, Chad and Mindy, to confront the Ghostface killer. The air is heavy with fear and uncertainty, as they know they are being hunted. Each character is on edge, their hearts racing, knowing that the killer could be lurking in the shadows.

The group discusses their next steps, revealing their internal struggles. Sam grapples with her identity and the legacy of her father, Billy Loomis, the original Ghostface. Tara, on the other hand, is determined to protect her sister and her friends, showcasing her growth from the previous film. Chad and Mindy, ever the horror movie enthusiasts, try to strategize, referencing classic horror tropes, but the reality of their situation weighs heavily on them.

As they prepare for the confrontation, the tension escalates. Suddenly, the lights flicker, and the familiar sound of the Ghostface theme echoes through the theater. The group splits up, each taking a different path, heightening the suspense. The camera follows Sam as she navigates the dark corridors, her heart pounding in her chest. She is determined to face her fears and confront the killer, embodying a mix of bravery and vulnerability.

In a shocking twist, the identity of the new Ghostface is revealed to be a character close to the group, igniting a wave of betrayal and disbelief. The killer explains their motivations, drawing parallels to the legacy of Ghostface and the impact it has had on their lives. This revelation adds a layer of complexity to the narrative, as the characters grapple with the idea of how trauma and violence can shape individuals.

The final showdown occurs in the theater's main stage, where the remaining characters confront the killer. A fierce battle ensues, filled with adrenaline and desperation. Sam, fueled by her desire to protect her sister and friends, fights back with a newfound strength. Tara, too, steps up, showcasing her resilience. The choreography of the fight is intense, with close calls and narrow escapes, as the characters use their knowledge of horror movie conventions to outsmart the killer.

In a climactic moment, Sam manages to overpower the Ghostface, delivering a final blow that brings the confrontation to an end. The killer lies defeated, and the weight of the moment settles over the group. They are left to process the trauma they have endured, but there is a sense of relief in their victory.

As the dust settles, the surviving characters gather, their expressions a mix of exhaustion and relief. Sam and Tara share a poignant moment, reaffirming their bond as sisters. Chad and Mindy, though shaken, find solace in their survival and the strength of their friendship. The film closes with a sense of closure for the characters, but the lingering question of Ghostface's legacy remains, hinting at the possibility of future threats.

In the aftermath, Sam, Tara, Chad, and Mindy emerge from the theater, forever changed by their experiences. They walk into the dawn of a new day, united in their survival but haunted by the memories of what they have faced. The film ends on a note of ambiguity, leaving the audience to ponder the cyclical nature of horror and the impact of trauma on the human psyche.

In Scream VI, there is indeed a post-credit scene that adds an intriguing layer to the film's conclusion. After the credits roll, the screen fades back in to reveal a dimly lit room filled with various horror memorabilia, including masks and props from previous Ghostface killings. The camera slowly pans across the room, creating a sense of unease and nostalgia for fans of the franchise.

As the camera continues to move, it settles on a figure sitting in the shadows, their face obscured. The figure is seen meticulously assembling a new Ghostface mask, hinting at the possibility of a new killer emerging. The sound of a knife being sharpened echoes in the background, heightening the tension.

Suddenly, the figure leans forward into the light, revealing a familiar face from the franchise, suggesting that they may have a significant role in the next installment. The scene ends with the chilling sound of the iconic Ghostface voice saying, "What's your favorite scary movie?" This leaves viewers with a sense of dread and anticipation, teasing the potential for more chaos and horror in the future.

In Scream VI, the Ghostface mask symbolizes the legacy of horror and the cycle of violence that continues to haunt the characters. It serves as a reminder of the past killings and the trauma that the survivors carry. The mask's presence evokes fear and nostalgia, as it connects the new generation of characters to the original events of the franchise.

Sam Carpenter, portrayed by Melissa Barrera, grapples with her identity and the weight of her family's legacy as the daughter of Billy Loomis. Throughout Scream VI, she struggles with her darker impulses and the fear of becoming like her father. Her journey is marked by moments of vulnerability and strength, as she learns to embrace her role as a protector of her friends while confronting her own demons.

Tara Carpenter, played by Jenna Ortega, is central to the plot of Scream VI as she navigates the aftermath of the previous Ghostface killings. Her character is marked by resilience and determination, as she seeks to reclaim her life while dealing with the trauma of being a target. Tara's relationship with her sister Sam is pivotal, showcasing themes of loyalty and the bond between siblings as they face the new threat together.

Scream VI introduces several new characters, including Mindy Meeks-Martin and Chad Meeks-Martin, who are the surviving members of the previous Ghostface attacks. Their knowledge of horror tropes and their connection to the original events provide crucial insights into the new killings. Additionally, new characters like Ethan and Quinn add layers of complexity and suspicion, as their true intentions and connections to the Ghostface legacy unfold throughout the film.

The relationship between the survivors and the new Ghostface killer in Scream VI is fraught with tension and fear. The killer targets the survivors, using their past experiences against them, which creates a psychological game of cat and mouse. The survivors must confront their own fears and insecurities while trying to uncover the identity of the killer, leading to a deeper exploration of trust and betrayal among friends.

Scream VI, produced in 2023, is not considered family-friendly due to its intense horror elements and graphic content. Here are some potentially objectionable or upsetting aspects that may occur:

1. Graphic Violence: The film features several scenes of brutal killings and gore, which may be disturbing for children and sensitive viewers.

2. Jump Scares: There are numerous jump scares designed to elicit shock and fear, which can be unsettling.

3. Psychological Tension: The film explores themes of trauma and fear, which may be emotionally intense for younger audiences.

4. Strong Language: The dialogue includes frequent use of profanity, which may not be suitable for children.

5. Mature Themes: The storyline delves into themes of revenge, betrayal, and the impact of past traumas, which may be complex and distressing for younger viewers.

6. Disturbing Imagery: There are scenes that may include unsettling visuals, such as blood and injuries, that could be upsetting.

Overall, Scream VI is intended for a mature audience and may not be appropriate for children or those sensitive to horror content.