The movie Novocaine produced in 2025 does not contain a post-credits scene. Multiple sources confirm that the film does not include any additional scenes during or after the credits, maintaining a self-contained narrative.

However, there is a misleading YouTube video that inaccurately describes a post-credits scene for Novocaine, suggesting a mysterious figure watching a news report about Nathan's heroic actions and hinting at future plots. This description is not accurate according to reliable sources.

Nathan Caine has congenital insensitivity to pain with anhidrosis (CIPA), a genetic disorder that prevents him from feeling pain. This condition forces him to set timers every three hours to use the bathroom to avoid injury, and he sustains himself on an all-liquid diet to prevent accidentally biting his tongue. His inability to feel pain is inconvenient and limiting but becomes crucial during the bank robbery and subsequent events.

On Christmas Eve, a gang of robbers dressed as Santa Claus, led by Simon Greenly, storm the credit union where Nathan works. They murder Nathan's boss Nigel and take his co-worker Sherry Margrave hostage. Nathan impulsively steals a police car to pursue them but mistakenly follows the wrong vehicle, leading to a confrontation with one of the robbers, Ben Clark, whom he eventually kills after a struggle.

Roscoe Dixon is Nathan's only friend, a gamer whom Nathan has never met in person. Nathan contacts Roscoe for help in tracking down the robbers after the bank heist. Roscoe assists Nathan in overcoming obstacles, including helping him escape a booby-trapped house and overpowering Ben's brother Andre, who tortures Nathan.

Sherry Margrave is Nathan's co-worker who is romantically interested in him. Initially, Nathan is hesitant due to his condition and inexperience with women. After an encounter with Nathan's middle-school bully, Sherry helps Nathan get revenge, and they eventually have sex. Their relationship deepens before the bank robbery, which leads Nathan to risk everything to rescue her.

After the robbery, Nathan pursues the robbers, leading to violent confrontations including a shootout in a restaurant kitchen where Nathan kills Ben Clark. He then investigates Ben's connections, leading to a booby-trapped house where he is captured and tortured by Ben's brother Andre. With Roscoe's help, Nathan kills Andre. Later, police officers arrive and arrest Roscoe, who has switched clothes with Nathan to protect him.