Bono explores his relationships with family, especially his father, friends, and his wife Alison Stewart, highlighting moments like his father's subtle pride and his long marriage of over fifty years.

The film covers Bono's activism and fights against injustice, showing his awareness of his own privilege while engaging in pro-Africa and anti-poverty stances, and his reflections on the motivations and results of his social efforts.

Music is central, with Bono sharing life stories alongside U2 songs in an intimate show format, including performances that break the fourth wall and blend presentation with openness, emphasizing the connection between his songs and personal experiences.

The film reveals Bono's self-righteousness and pretentiousness at times, showing his ego and boldness, but also includes moments of humility and humor, such as anecdotes about his father and his own youthful unreasonableness.

The film uses theatrical devices like breaking the fourth wall, staged conversations with his father, and reminders of the performance's constructed nature, blending storytelling with live concert elements to humanize and deepen the narrative.